Selected Publications

PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy  John M. Fidler, Ke Li, Cathie Chung, Ke Wei, Jessica A. Ross, MingXing Gao, and Glenn D. Rosen; Mol. Canc. Ther. 2, 855 (2003).

Immunosuppressive activity of the Chinese medicinal plant Tripterygium wilfordii. III. Suppression of graft-versus-host disease in murine allogeneic bone marrow transplantation by the PG27 extract  John M. Fidler, Geoffrey Y. Ku, Duane Piazza, Rensheng Xu, Renling Jin, and Zhenqing Chen; Transplantation 74, 445 (2002).

PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model  Colm T. Leonard, Paola M. Soccal, Gerald J. Berry, Ramona L. Doyle, James Theodore, Steven R. Duncan, and Glenn D. Rosen; J Heart Lung Transplant. 21, 1314-8 (2002). 

PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis  Ganesh Krishna, Kela Liu, Hidenobu Shigemitsu, MingXing Gao, Thomas A. Raffin and Glenn D. RosenAm. J. Pathol. 158, 997-1004 (2001).

Triptolide and Chemotherapy Cooperate in Tumor Cell Apoptosis  Wen-The Chang, Jason J. Kang, Kye-Young Lee, Ke Wei, Emily Anderson, Sonali Gotmare, Jessica A. Ross, and Glenn D. Rosen; The Journal of Biological Chemistry, Vol. 276, 2221-2227, No.3, January 19, 2001.

Prevention of graft-versus-host disease by a Novel Immunosuppressant, PG490-88, Through Inhibition of Alloreactive T Cell Expansion Benny Chenn, Conxiao Liu, Xiuyu Cui, John M. Fidler, and Nelson Chao; Transplantation, Vol. 70, 1442-1447, No.10, November 27, 2000.

Triptolide Attentuates Pulmonary Arterial Hypertension and Neointimal Formation in Rats John L. Faul, Toshihiko Nishimura, Gerald J. Berry, Gail V. Benson, Ronald G. Pearl, and Peter N. Kao; Am J Respir Crit Care Med, Vol., 162, 2252-2258, 2000.

Immunosuppressant Activity of the Chinese Medicinal Plant Tripterygium WilfordII, II. Prolongation of Hamster-to Rat Cardiac Xenograft Survival by Combination Therapy with the PG27 Extract and Cyclosporine  Jian Wang, Rensheng Xu, Renling Jin, Zhenqing Chen, and John M. Fidler, Transplantation, Vol. 70, 456-464, No. 3, August 15, 2000.

Immunosuppressant Activity of the Chinese Medicinal Plant Tripterygium WilfordII, I. Prolongation of Rat Cardiac and Renal Allograft Survival by the PG 27 Extract and Immunosuppressive Synergy in Combination Therapy with Cyclosporine  Jian Wang, Rensheng Xu, Renling Jin, Zhenqing Chen, and John M. Fidler, Transplantation, Vol. 70, 447-455, No. 3, August 15, 2000.

Anti-inflamatory Effect of Triptolide in Human Bronchial Epithelial Cells Guohua Zhao, Laszlo T. Vaszar, Daoming Qiu, Lingfang Shi, and Peter N. Kao, Am J Physiol Lung Cell Mol Physiol, 279, L958-966, 2000.

PG27, an Extract of Tripterygium Wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation  Yanfei Chen, Defu Zeng, Paul G. Schlegel, John M. Fidler and Nelson J. Chao, Blood, 95, 705-710, 2000.

PG 490 ( Triptolide) Cooperates with Tumor Necrosis Factor-a to Induce Apoptosis in Tumor Cells Kye Young Lee, Wen-teh Chang, Daoming Qiu, Peter N. Kao and Glenn D. Rosen, The Journal of Biological Chemistry, Vol. 274, No. 19 13451-13455, May 7, 1999.

Immunosuppressant PG490 (Triptolide) Inhibits T-cell Interleukin-2 Expression at the Level of Purine-box/Nuclear Factor of Activated T-cells and NK-kB Transcriptional Activation  Daoming Qiu, Grohua Zhao, Yosuke Aoki, Lingfang Shi, Anne Uyei, Saman Nazarian, James C.-H. Ng, and Peter N. Kao; The Journal of Biological Chemistry, Vol. 274, No.19, 13443-13450, May 7, 1999.

 

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